A Simple Key For rheumatoid arthritis pdf Unveiled


Worldwide, more people suffer from the inability of their immune systems to distinguish between healthy cells and invading microscopic organisms. Instead of protecting themselves from illness, their organs and tissue are being attacked by these same defenses.




A major international effort in research is underway to stop this trend. A London-based initiative called the Francis Crick Institute, has two world-renowned experts. James Lee & Carola Vinuesa set up separate research teams to figure out the exact causes of an autoimmune disorder.


Lee stated to the Observer the Observer that autoimmune diseases were increasing in the West in the past 40 years. But, some of these cases are now being observed in countries that have not experienced such diseases.


For instance for instance, the Middle East and East Asia are the regions with the highest percentage of cases of inflammatory bowel disease. Before that they had hardly had any experience with the disease.


Autoimmune diseases can range from type 1 diabetes to rheumatoid arthritis inflammation of the bowel and multiple sclerosis. In each case the immune system focuses on healthy tissues, not infectious agents.


Around four million people living in the UK have been affected by these conditions. Others may suffer more than one. In the world, it's thought that the number of autoimmune disorders is increasing at the rate of 3%-9% per annum. The rise in cases of autoimmune diseases is believed to be due to environmental factors, according to the majority of researchers.


Lee who was based in Cambridge University, stated that genetics has not changed over the last few decades. It seems that something is going on in the outside world which is increasing our vulnerability to autoimmune disease.


Vinuesa who used to be situated at the Australian National University supported the idea. She noted that there had been changes in diet because more people were eating western-style meals, as well as increasing consumption of fast food.


Vinuesa noted that fast-food dishes are deficient in certain essential ingredients like fiber. The evidence suggests that this can alter the microbiome of a person which is the accumulation of microorganisms living in our gut. These microorganisms play an vital role in regulating many bodily functions.


The microbiome's changes can then trigger autoimmune diseases. More than 100 different types of autoimmune disorders have been identified.


Both scientists stressed that there were individual susceptibilities to the diseases. It includes celiac as well as Lupus. It causes inflammation, swelling, and may cause harm and even death to various organs, including the heart.


"If you don't possess a particular genetic susceptibility, you won't necessarily get an autoimmune disorder, no matter how many Big Macs you consume," said Vinuesa. "We are unable to slow the growth of fast-food chains around the world. Instead, we're working to understand how autoimmune diseases are caused and what genetic causes make certain people more susceptible to autoimmune diseases than others. That's the level where we plan to address this issue."


Scientists are now able to identify tiny differences in DNA among large numbers of individuals. This is possible because of the advancement of technology. This allows us to find the common genetic traits in people with autoimmune diseases.


Lee stated that up until recent, we didn't have the tools necessary to identify DNA. Now, we have this amazing power and it has transformed everything. We had only half a dozen variants of DNA that can trigger intestinal inflammation when I started my study. Now, we know over 250.


Lee and Vinuesa focus their energies on this kind of work. They seek to understand more about the genetic pathway and find the causes of the different diseases they're studying. Vinuesa believes it's now evident that there are many types of autoimmune conditions, like Lupus. They could all be caused by various genetic pathways. And that has a consequence when trying to find the right treatment.


Although there are many potentially effective new therapies in development, we don't yet know the patients they should be offered to. This is due to the fact that we aren't able to pinpoint the specific type of condition. That is why autoimmune research has become a priority. We must learn to classify and stratify patients so that we can provide them with the appropriate therapy.


Lee explained that the increasing incidence of autoimmune diseases around the world means the development of new therapies and medicines is required now more than ever before. According to Lee, today there is no cure for autoimmune disorders. They are most often seen in teens who are trying to complete their education and get an employment.


This means that more patients are scheduled for surgery or have to have regular injections for the remainder of their lives. It can be a stressful time for patients, and can put an huge strain on the healthcare system. We need new and effective treatments.


Rheumatoid Arthritis is an autoimmune condition. This means that the immune system attacks healthy tissues. We don't know Read More the triggers for it.


The antibodies that your immune system makes to attack bacteria and viruses is the ones you require to fight infections.


If you suffer from Rheumatoid arthritis, your immune systems mistakenly transmits antibodies to your joints the lining of your joints, and they attack the surrounding tissues.


The thin layer, called synovium of cells that surround your joints to become sore. It also releases chemicals that could cause injuries to the area.


bones

Cartilage, which is the connective tissue between bones.

Tendons are Check out the connective tissue that connects bone to muscles.

Ligaments are the connective tissue that connects bone and cartilage.

If rheumatoid isn't treated, the chemicals slowly cause the joint lose its shape. The result could be irreparable.


While there are many theories about how the immune system targets joints, none has been confirmed.


Possible risk factors



You could be at greater risk for developing rheumatoid arthritis if you do not take these steps:


Your genes - Some evidence suggests that rheumatoid joint disease can be passed down through families. However, it is unlikely that you'll inherit the disease. Genetics are thought to play a small part in the.

Hormones: Rheumatoid arthritis is more prevalent than ever before in women, possibly due to the hormone effects of oestrogen. This link, however it has not been proved.

Smoking - Evidence suggests that those who smoke are more likely to develop rheumatoid arthritis.

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